Chromatin disassembly and reassembly during DNA repair
نویسندگان
چکیده
منابع مشابه
Chromatin Challenges during DNA Replication and Repair
Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin...
متن کاملChromatin dynamics and DNA repair.
Packing of the eukaryotic genome into chromatin poses an accessibility problem for the DNA repair machinery. Chromatin structure has to be changed for the repair to occur, and we are beginning to discover how different chromatin modifying mechanisms facilitate DNA repair in the chromatin context. On the other hand, the repair-related changes in chromatin should be transient, and a particular ch...
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Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging...
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Chromatin structure is modulated during deoxyribonucleic acid excision repair, but how this is achieved is unclear. Loss of the yeast Ino80 chromatin-remodeling complex (Ino80-C) moderately sensitizes cells to ultraviolet (UV) light. In this paper, we show that INO80 acts in the same genetic pathway as nucleotide excision repair (NER) and that the Ino80-C contributes to efficient UV photoproduc...
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Efficient procedures are described for the disassembly of Cowpea Chlorotic Mottle Virus (CCMV) into its viral-RNA and capsid-protein components, the separation of the RNA and protein, and the reassembly of the purified protein into higher order nanoscale structures. These straightforward biochemical techniques result in high yield quantities of protein suitable for further biophysical studies (...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2007
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2006.05.039